The Molecular Basis of Cluster Formation by Membrane-Bound Lipidated Ras
نویسندگان
چکیده
منابع مشابه
Membrane localization and flexibility of a lipidated ras peptide studied by molecular dynamics simulations.
Lipid-modified membrane-binding proteins are essential in signal transduction events of the cell, a typical example being the GTPase ras. Recently, membrane binding of a doubly lipid-modified heptapeptide from the C-terminus of the human N-ras protein was studied by spectroscopic techniques. It was found that membrane binding is mainly due to lipid chain insertion, but it is also favored by int...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.1429